MS432

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Cat. No.: IBDI-434938

MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively.

Size (Solid):

Product Details

Target	PROTACs \| MEK
Molecular Weight	1076.06
Appearance	Solid
SMILES	O=C([[email protected]]1N(C([[email protected]](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[[email protected]](O)C1)N[[email protected]](C4=CC=C(C5=C(C)N=CS5)C=C4)C
Purity	98.20%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.