NecroIr1

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Cat. No.: IBDI-432946

NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Mixed Lineage Kinase \| RIP kinase \| CDK
Molecular Weight	823.36
Appearance	Solid
SMILES	CC1=CC(C2=[N]3C=CC(C4=NC(C=CC=C5)=C5O4)=C2)=[N]([Ir]67([N]8=CC=CC=C8C9=C7C=CC=C9)3[N]%10=CC=CC=C%10C%11=C6C=CC=C%11)C=C1.[+].[Cl-]
Purity	98.02%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.