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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Nemorubicin

Cat. No.: IBDI-433783

Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity.

Size (Solid):

Product Details

Target G-quadruplex
Molecular Weight 643.64
Appearance Solid
Synonyms Methoxymorpholinyl doxorubicin, FCE 23762, PNU 152243
SMILES COC1=C2C(C(C3=C(O)C(C[[email protected]](C(CO)=O)(O)C[[email protected]]4([H])O[[email protected]]5C[[email protected]](N6CCO[[email protected]](OC)C6)[[email protected]](O)[[email protected]](C)O5)=C4C(O)=C3C2=O)=O)=CC=C1
Purity 95.76%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Powder: -20°C/3 years; 4°C/2 years
In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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