NHEJ inhibitor-1

Cat. No.: IBDI-431891

NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the  non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin。NHEJ inhibitor-1 also induces ROS generation and MMP deduction.

Product Details

Target	Reactive Oxygen Species
Molecular Weight	848.79
SMILES	[H][[email protected]]12CS[[email protected]]([[email protected]]1(NC(N2)=O)[H])CCCCC(NCCN3C(C4=CC=CC5=C4C(C3=O)=CC=C5/N=C6CC7(C(O[Pt]([NH3])(OC7=O)[NH3])=O)C/6)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.