NLRP3-IN-NBC6

Cat. No.: IBDI-432644

NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Product Details

Target	NOD-like Receptor (NLR)
Molecular Weight	409.50
Appearance	Solid
SMILES	CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.