Cat. No.: IBDA-431587
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Online InquiryTarget Information
| Target Name | NLRP3 |
| Uniprot ID | Q96P20 |
| Cellular Localization | Cytoplasm. |
| Immunogen | Recombinant fragment. |
| Function | May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. |
Product Details
| Description | Rabbit monoclonal antibody to NLRP3. |
| Host Species | Rabbit |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse |
| Immunogen | Recombinant fragment. |
| Positive Control | WB: RAW 264.7 (+/- treatment with LPS) and J774A.1 whole cell lysates. ICC/IF: RAW 264.7 (+ treatment with LPS) cells. IP: RAW 264.7 (+ treatment with LPS) whole cell lysate. |
| Application | ICC/IF, IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.01% Sodium Azide Constituent: PBS, 40% Glycerol, 0.05% BSA |
| Handling | Avoid freeze-thaw cycles. |