NLRP3 Polyclonal Antibody

Target Information

Target Name	NLRP3
Uniprot ID	Q96P20
Cellular Localization	Cytoplasm.
Immunogen	Synthetic peptide corresponding to Human NLRP3 aa 1024-1036 (C terminal).
Function	May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Product Details

Description	Goat polyclonal antibody to NLRP3.
Host Species	Goat
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to Human NLRP3 aa 1024-1036 (C terminal).
Positive Control	Flow Cyt (Intra): U937 cells. WB: THP-1 cells
Application	Flo, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	pH: 7.30 Preservative: 0.02% Sodium Azide Constituent: 0.5% BSA, Tris Buffered Saline
Handling	Avoid freeze-thaw cycles.