Cat. No.: IBDA-431745
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Online InquiryTarget Information
| Target Name | NLRX1 |
| Uniprot ID | Q86UT6 |
| Cellular Localization | Mitochondrion outer membrane. |
| Immunogen | Synthetic peptide within Human NLRX1 aa 150-250 conjugated to keyhole limpet haemocyanin. |
| Function | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). |
Product Details
| Description | Rabbit polyclonal antibody to NLRX1. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Protein A purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide within Human NLRX1 aa 150-250 conjugated to keyhole limpet haemocyanin. |
| Positive Control | Human breast carcinoma and mouse embryonic muscle tissues. |
| Application | IHC-P |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.2 Preservative: 0.09% Sodium Azide Constituent: 50% Glycerol, 1% BSA |
| Handling | Avoid freeze-thaw cycles. |