Nonactin

Cat. No.: IBDI-430223

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K +, and NH4 +. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60.

Product Details

Target	Potassium Channel | Mitochondrial Metabolism | Bacterial | Influenza Virus | Apoptosis | Antibiotic
Molecular Weight	736.93
Appearance	Solid
Synonyms	Ammonium ionophore I
Structure Classification	Antibiotics>Macrolide Antibiotics
Purity	≥99.0%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.