NRAMP1 Polyclonal Antibody

Target Information

Target Name	NRAMP1
Uniprot ID	P49279
Cellular Localization	Membrane.
Immunogen	Synthetic peptide corresponding to Human NRAMP1 aa 250-350 (internal sequence) conjugated to keyhole limpet haemocyanin.
Function	Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Product Details

Description	Rabbit polyclonal antibody to NRAMP1.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to Human NRAMP1 aa 250-350 (internal sequence) conjugated to keyhole limpet haemocyanin.
Positive Control	Human tonsil tissue, CEM whole cell lysate.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.4 Preservative: 0.09% Sodium Azide Constituent: 99% PBS
Handling	Avoid freeze-thaw cycles.