Okadaic acid ammonium salt

Cat. No.: IBDI-434698

Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation.

Product Details

Target	Phosphatase
Molecular Weight	822.03
SMILES	O[[email protected]](CC1)[[email protected]@](O[[email protected]@H]1C[[email protected]@](C)(O)C([O-])=O)(C=C2C)O[[email protected]](C2)([H])[[email protected]](C)/C=C/[[email protected]@H]3O[[email protected]@]4(O[[email protected]]([[email protected]@H](C5=C)O)([H])[[email protected]@](O[[email protected]]5([H])[[email protected]@H](O)C[[email protected]@H]([[email protected]@]6([H])O[[email protected]@]7(CCCCO7)CC[[email protected]]6C)C)([H])CC4)CC3.[NH4+]

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.