Oprozomib

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Cat. No.: IBDI-432366

Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	Proteasome \| Autophagy \| Apoptosis
Molecular Weight	532.61
Appearance	Solid
Synonyms	ONX 0912, PR-047
SMILES	C[[email protected]]1(OC1)C([[email protected]](CC2=CC=CC=C2)NC([[email protected]@H](NC([[email protected]@H](NC(C3=CN=C(C)S3)=O)COC)=O)COC)=O)=O
Purity	99.71%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.