p-nitro-Pifithrin-α

Cat. No.: IBDI-434388

p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet . non-alcoholic fatty liver disease.

Product Details

Target	MDM-2/p53 | TGF-β Receptor | Caspase
Molecular Weight	398.27
SMILES	N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.