Cat. No.: IBDA-431819
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Online InquiryTarget Information
| Target Name | p38 (phospho T180 + Y182) |
| Uniprot ID | Q16539 |
| Cellular Localization | Cytoplasm. Nucleus. |
| Immunogen | Synthetic peptide corresponding to Rat p38 (phospho T180 + Y182) conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Function | Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis. |
Product Details
| Description | Mouse monoclonal antibody to p38 (phospho T180 + Y182). |
| Host Species | Mouse |
| Clonality | Monoclonal |
| Purity | Protein A purified |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide corresponding to Rat p38 (phospho T180 + Y182) conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Positive Control | Pervanadate treated human Jurkat and A431 cells and anisomycin treated human HeLa cells. |
| Application | WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | Preservative: 0.05% Sodium Azide Constituent: PBS, 50% Glycerol, 0.1% BSA |
| Handling | Avoid freeze-thaw cycles. |