p38 (phospho T180 + Y182) Polyclonal Antibody

Target Information

Target Name	p38 (phospho T180 + Y182)
Uniprot ID	Q16539
Cellular Localization	Cytoplasm. Nucleus.
Immunogen	Synthetic peptide corresponding to Human p38 (phospho T180 + Y182).
Function	Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Product Details

Description	Rabbit polyclonal antibody to p38 (phospho T180 + Y182).
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Rat, Human
Immunogen	Synthetic peptide corresponding to Human p38 (phospho T180 + Y182).
Positive Control	WB: HeLa, A431, COLO 205, A549 and A549 cell lysate. HEK-293 (human epithelial cell line from embryonic kidney) cells. IHC-P: Human brain tissue, human heart tissue, rat heart tissue. ICC: SH-SY5Y (human neuroblastoma cell line from bone marrow) cells.
Application	ICC/IF, IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.30 Preservative: 0.05% Sodium Azide Constituent: PBS, 50% Glycerol, 0.1% BSA BSA is IgG and protease free. PBS Without Mg2+ and Ca2+.
Handling	Avoid freeze-thaw cycles.