Cat. No.: IBDRGCL60469
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| Synonyms | Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1 |
| Description | Recombinant CHO-K1 cells constitutively expressing human PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # NM_014143) and an engineered T cell receptor (TCR) activator. This cell lines was functionally validated in a cell-based assay. |
| Host Cell Line | CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent |
| Applications | • Screen for activators or inhibitors of PD-1 signaling in a cellular model. • Characterize the biological activity of PD-1 interactions with PD-L1. |
| Supplied As | Each vial contains >1 x 106 cells in 1 mL of cell freezing medium |
| Materials Required But Not Supplied | Media Required for Cell Culture • Thaw Medium 3 • Growth Medium 3A Materials Required for Cellular Assay • Thaw Medium 2 • PD-1/NFAT Reporter -Jurkat Recombinant Cell Line • NFAT Reporter (Luc) -Jurkat Recombinant Cell Line • Anti-PD-1 Neutralizing Antibody • Anti-PD-L1 (CD274) Neutralizing Antibody • 96-well tissue culture-treated white clear-bottom assay plate • Luminometer |
| UniProt | Q9NZQ7 |
| Mycoplasma Testing | The cell line has been screened to confirm the absence of Mycoplasma species. |
| Scientific Category | Immunotherapy |
Storage & Handling
| Storage/Stability | Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage. |
| Shipping Temperature | -80°C |
| Warnings | Avoid freeze/thaw cycles |
| Regulatory Status | Research Use Only |