PDE1-IN-4
Cat. No.: IBDI-432871
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.
Product Details
| Target |
PhosphodiesteRase (PDE) | Calcium Channel |
| Molecular Weight |
535.63 |
| SMILES |
CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[[email protected]@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[[email protected]@H](C5=CC=CC=C5)C)=O |
Storage & Handling
| Shipping |
Room temperature in continental US. May vary elsewhere. |
| Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| Regulatory Status |
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. |
! For research use only, not intended for any clinical use.
