Physalin H

Cat. No.: IBDI-431039

Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively.

Product Details

Target	Hedgehog | Endogenous Metabolite
Molecular Weight	562.99
SMILES	C[[email protected]@]([[email protected]](OC1=O)C2)(OC3=O)[[email protected]](O[[email protected]@]45C6=O)([[email protected]]3(CC[[email protected]@]([[email protected]]([[email protected]@]7(CC=C8)Cl)(C8=O)C)([H])[[email protected]@]4([H])C[[email protected]]7O)O)[[email protected]@]6([H])[[email protected]]2([[email protected]@]1([H])CO5)C
Structure Classification	Steroids>Cardiacglycosides

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.