PI 3 Kinase p85 Beta (phospho Y464) Polyclonal Antibody

Target Information

Target Name	PI 3 Kinase p85 Beta (phospho Y464)
Immunogen	Synthetic peptide corresponding to PI 3 Kinase p85 beta (internal sequence) (phospho Y464).
Function	Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

Product Details

Description	Rabbit polyclonal antibody to PI 3 Kinase p85 beta (phospho Y464).
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide corresponding to PI 3 Kinase p85 beta (internal sequence) (phospho Y464).
Positive Control	Jurkat cell extract.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C
Storage Buffer	pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: 49% PBS, 50% Glycerol, 0.88% Sodium Chloride
Handling	Avoid freeze-thaw cycles.