PI 3 Kinase p85 Beta Polyclonal Antibody

Target Information

Target Name	PI 3 Kinase p85 Beta
Immunogen	Synthetic peptide corresponding to Human PI 3 Kinase p85 beta aa 447-461 (internal sequence).
Function	Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

Product Details

Description	Rabbit polyclonal antibody to PI 3 Kinase p85 beta.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Immunogen affinity purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat, Human
Immunogen	Synthetic peptide corresponding to Human PI 3 Kinase p85 beta aa 447-461 (internal sequence).
Positive Control	WB: Rat testis tissue lysate and HeLa and 293T whole cell lysates. IHC-P: Human mammary cancer tissue.
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservatives: 0.025% Thimerosal (Merthiolate), 0.025% Sodium Azide Constituent: 2.5% BSA, 0.1% Dibasic Monohydrogen Sodium Phosphate, 0.45% Sodium Chloride
Handling	Avoid freeze-thaw cycles.