PKM2/PDK1-IN-1

Cat. No.: IBDI-433698

PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. PKM2/PDK1-IN-1 inhibits the proliferation of NSCLC cells, and induces apoptosis. PKM2/PDK1-IN-1 induces intercellular ROS production, and regulates the apoptotic proteins, to involves in mitochondrial and death receptor pathway.

Product Details

Target	Pyruvate Kinase | PDK-1 | Akt | EGFR | Apoptosis
Molecular Weight	697.92
SMILES	COC([[email protected]@H](NC(CCCC[[email protected]@H]1CCSC(S1)C2=C(C=CC=C2)C)=O)CS[[email protected]@H](C3=CC(C4=C(C=CC(O)=C4C3=O)O)=O)C/C=C(C)\C)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.