Cat. No.: IBDP-532640
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Online InquiryTarget Information
| Synonyms | 3D53 |
| Sequence | F-{Orn}-P-{d-Cha}-WR (Lactam bridge: Orn2- Arg6) |
| Function | PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects. |
Product Details
| Product Type | Peptide |
| Cas | 219639-75-5 |
| Molecular Weight | 896.09 kDa |
| Purity | 0.9807 |
Storage & Handling
| Shipping | Shipped at Room Temperature. |
| Storage | Store at -20 °C or -80 °C. |
| Handling | Avoid freeze / thaw cycle. |