Cat. No.: IBDAK-620112
Size:
Online InquiryOverview
| Sample Type | Adherent cells, Suspension cells, Nuclear Extracts |
| Detection Method | Colorimetric |
| Assay Type | Semi-quantitative |
| Product Type | Redox Metabolism |
| Species Reactivity | Reacts with: Mouse, Rat, Human Predicted to work with: Mammals |
| Platform | Microplate reader |
Target
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. |
| Tissue Specificity | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
| Sequence Similarities | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Cellular Localization | Nucleus. |
Storage & Handling
| Storage | Store at +4°C. |
| Storage Buffer | Constituent: 100% PBS |