PR-924

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Cat. No.: IBDI-435940

PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities.

Size (Solid):

Product Details

Target	Proteasome \| Apoptosis
Molecular Weight	618.72
Appearance	Solid
SMILES	O=C(N[[email protected]@H](CC1=CC=CC=C1)C([[email protected]]2(CO2)C)=O)[[email protected]@H](NC([[email protected]@H](C)NC(C(CC3=CC=CC=C43)=C4C)=O)=O)CC5=CNC6=CC=CC=C56
Purity	99.34%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.