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PRMT5-IN-1 hydrochloride

Cat. No.: IBDI-434658

PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions.

Size (Solid):

Product Details

Target Histone MethylTransfeRase
Molecular Weight 455.29
Appearance Solid
SMILES O[[email protected]@H]1[[email protected]@H]([[email protected]@H](C2=CC=C(Cl)C=C2)O)O[[email protected]@H](N3C=CC4=C3N=CN5C4=NCC5O)[[email protected]@H]1O.[H]Cl
Purity 99.50%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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