PROTAC AR-V7 degrader-1

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Cat. No.: IBDI-435780

PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	PROTACs \| Androgen Receptor
Molecular Weight	789.02
Appearance	Solid
SMILES	O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[[email protected]@H](C(C)(C)C)C(N4[[email protected]@H](C[[email protected]](C4)O)C(N[[email protected]](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
Purity	99.34%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.