PROTAC Bcl-xL degrader-1

Cat. No.: IBDI-433437

PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP; E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively.

Product Details

Target	PROTACs | Bcl-2 Family
Molecular Weight	1514.28
SMILES	ClC1=CC=C(C=C1)C2=C(CC(C)(CC2)C)CN3CCN(CC3)C4=CC=C(C=C4)C(NS(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[[email protected]](CCN6CCN(CC6)C(CCCOC7=CC8=C(C=C7)[[email protected]](NC([[email protected]@H]9C(C)(C[[email protected]@]([H])(N9C%10=O)OCC[[email protected]@H]%10NC([[email protected]@H](NC)C)=O)C)=O)CCC8)=O)CSC%11=CC=CC=C%11)(=O)=O)=O

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.