PROTAC BRD4 Degrader-13

Cat. No.: IBDI-432704

PROTAC BRD4 Degrader-13 (compound 9d) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively.

Product Details

Target	PROTACs | Epigenetic Reader Domain | ADC Cytotoxin
Molecular Weight	1492.54
SMILES	CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]](CN3C([[email protected]@H](NC(CCCCCCCCCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OP(OP(OCCNC(CCCCCN9C(C=CC9=O)=O)=O)(O)=O)(O)=O)=O)C=C2

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.