PROTAC EGFR degrader 2

Cat. No.: IBDI-434000

PROTAC EGFR degrader 2 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 2 exhibits excellent antiproliferative activity with IC50 of 4.0 nM and good EGFR degradation activity with DC50 of 36.51 nM. PROTAC EGFR degrader 2 can be used for the synthesis of nitroreductase (NTR)-responsive PROTAC.

Product Details

Target	PROTACs | EGFR
Molecular Weight	1151.78
SMILES	FC(C=CC(NC1=NC=NC2=CC(OCCCCCC3=CN(N=N3)CCOCCOCC(N[[email protected]](C(N4C[[email protected]@H](C[[email protected]]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)C(C)(C)C)=O)=C(C=C21)NC(/C=C/CN7CCCCC7)=O)=C8)=C8Cl

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.