PSMA7/HSPC Monoclonal Antibody

Target Information

Target Name	PSMA7/HSPC
Uniprot ID	O14818
Cellular Localization	Cytoplasm. Nucleus.
Immunogen	Synthetic peptide within Human PSMA7/HSPC aa 1-100.
Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Product Details

Description	Rabbit monoclonal antibody to PSMA7/HSPC.
Host Species	Rabbit
Clonality	Monoclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Human
Immunogen	Synthetic peptide within Human PSMA7/HSPC aa 1-100.
Positive Control	A549, MCF7, 293T, and HeLa cell lysates, Human breast carcinoma tissue
Application	IHC-P, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C
Storage Buffer	pH: 7.2 Preservative: 0.05% Sodium Azide Constituent: 40% Glycerol, 9.85% Tris Glycine, 50% Tissue Culture Supernatant
Handling	Avoid freeze-thaw cycles.