RANTES Polyclonal Antibody

Target Information

Target Name	RANTES
Uniprot ID	P13501
Cellular Localization	Secreted.
Immunogen	Recombinant fragment, corresponding to amino acids 1-70 of mature Rat RANTES.
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

Product Details

Description	Rabbit polyclonal antibody to RANTES.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein A purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse, Rat
Immunogen	Recombinant fragment, corresponding to amino acids 1-70 of mature Rat RANTES.
Application	WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	Preservative: 0.1% Sodium Azide Constituent: PBS
Handling	Avoid freeze-thaw cycles.