RANTES Polyclonal Antibody

Target Information

Target Name	RANTES
Uniprot ID	P13501
Cellular Localization	Secreted.
Immunogen	Recombinant fragment corresponding to Rat RANTES aa 1 to the C-terminus.
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.

Product Details

Description	Biotin Rabbit polyclonal antibody to RANTES.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Affinity purified
Isotype	IgG
Conjugation	Biotin
Reactivity	Recombinant fragment
Immunogen	Recombinant fragment corresponding to Rat RANTES aa 1 to the C-terminus.
Application	ELISA, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20ºC. Store in the dark
Storage Buffer	Constituent: PBS, 0.1% BSA
Handling	Avoid freeze-thaw cycles.