Recombinant Human IKB beta Protein

Target Information

Sequence	Purity was determined to be>90% by densitometry.
Sequence Similarities	Belongs to the NF-kappa-B inhibitor family. Contains 6 ANK repeats.
Cellular Localization	Cytoplasm. Nucleus.
Tissue Specificity	Expressed in all tissues examined.
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Product Details

Product Type	Protein
Species	Human
Source	E. coli
Protein Length	Full length protein
Purity	>90%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE, WB

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -20 °C or -80 °C.
Handling	Avoid freeze / thaw cycle.