Recombinant Human PDGFR beta Protein

Target Information

Sequence	MASMTGGQQMGRGHHHHHHENLYFQGGEFLVVTPPGPELVLNVSSTFVLT CSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHN DSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTD PQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDA YYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKE SGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDE KAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKD NRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDA EVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRD LKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRP LSVRCTLRNAVGQDTQEVIVVPHSLPFKV
Sequence Similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
Amino Acids	33 to 532
Cellular Localization	Membrane.
Function	Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.

Product Details

Product Type	Protein
Species	Human
Source	E. coli
Tag	His-T7 Tag
Protein Length	Protein fragment
Molecular Weight	60 kDa
Purity	>90%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C.
Handling	Avoid freeze / thaw cycle.