Recombinant Human PI3-kinase p85 alpha Protein

Target Information

Sequence	MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARP EEIGWLNGYN ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVA PGSSKTEADVEQQALTLPDLAE QFAPPDIAPPLLIKLVEAIEKKGLEC STLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH VLADAFKRYLLDLP NPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL QY LLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEI LISTEWNE RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISR EEVNEKLRDTADGTFLVRDA STKMHGDYTLTLRKGGNNKLIKIFHRDG KYGFSDPLTFSSVVELINHYRNESLAQYNPKL DVKLLYPVSKYQQDQV VKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK RTAI EAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSR ISEIID SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLM WLTQKGVRQKKLNEWLGN ENTEDQYSLVEDDEDLPHHDEKTWNVGSSN RNKAENLLRGKRDGTFLVRESSKQGCYACS VVVDGEVKHCVINKTATG YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA QQRR
Sequence Similarities	Belongs to the PI3K p85 subunit family. Contains 1 Rho-GAP domain. Contains 2 SH2 domains. Contains 1 SH3 domain.
Amino Acids	1 to 724
Tissue Specificity	Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Function	Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Product Details

Product Type	Protein
Species	Human
Source	Baculovirus Infected Sf9 Cells
Tag	His
Protein Length	Full length protein
Purity	>95%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE, WB

Storage & Handling

Shipping	Shipped with Dry Ice.
Storage	Store at -20 °C or -80 °C.
Handling	Avoid freeze / thaw cycle.