Cat. No.: IBDP-530833
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Online InquiryTarget Information
| Sequence Similarities | Belongs to the PI3K p85 subunit family. Contains 1 Rho-GAP domain. Contains 2 SH2 domains. Contains 1 SH3 domain. |
| Amino Acids | 1 to 1068 |
| Tissue Specificity | Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). |
| Function | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. |
Product Details
| Product Type | Protein |
| Species | Human |
| Source | Baculovirus Infected Sf9 Cells |
| Tag | DDDDK Tag |
| Protein Length | Full length protein |
| Molecular Weight | 208 kDa |
| Purity | ≥95% |
| Active | Yes |
| Animal free | No |
| Nature | Recombinant |
| Application | FuncS, SDS-PAGE |
Storage & Handling
| Shipping | Shipped with Dry Ice. |
| Storage | Store at -80 °C. |
| Handling | Avoid freeze / thaw cycle. |