Recombinant Mouse CD14 Protein

Target Information

Sequence	SPAPPEPCELDEESCSCNFSDPKPDWSSAFNCLGAADVELYGGGRSLEYL LKRVDTEADLGQFTDIIKSLSLKRLTVRAARIPSRILFGALRVLGISGLQ ELTLENLEVTGTAPPPLLEATGPDLNILNLRNVSWATRDAWLAELQQWLK PGLKVLSIAQAHSLNFSCEQVRVFPALSTLDLSDNPELGERGLISALCPL KFPTLQVLALRNAGMETPSGVCSALAAARVQLQGLDLSHNSLRDAAGAPS CDWPSQLNSLNLSFTGLKQVPKGLPAKLSVLDLSYNRLDRNPSPDELPQV GNLSLKGNPFLDSESHSEKFNSGVVTAGAPSSQAVALSGTLALLLGDRLF VHHHHHH
Sequence Similarities	Contains 11 LRR (leucine-rich) repeats.
Amino Acids	16 to 366
Cellular Localization	Cell membrane.
Tissue Specificity	Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Function	Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Product Details

Product Type	Protein
Species	Mouse
Source	Insect Cells
Tag	His
Endotoxin Level	<1.0 Eu/µg
Protein Length	Full length protein
Molecular Weight	38 kDa
Purity	>90%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20 °C.
Handling	Avoid freeze / thaw cycle.