Recombinant Mouse Dectin-1 Protein

Target Information

Sequence	FWRHNSGRNP EEKDNFLSRN KENHKPTESS LDEKVAPSKA SQTTGGFSQP CLPNWIMHGK SCYLFSFSGN SWYGSKRHCS QLGAHLLKID NSKEFEFIES QTSSHRINAF WIGLSRNQSE GPWFWEDGSA FFPNSFQVRN TAPQESLLHN CVWIHGSEVY NQICNTSSYS ICEKEL
Sequence Similarities	Contains 1 C-type lectin domain.
Amino Acids	69 to 244
Cellular Localization	Cytoplasm and Cell membrane.
Tissue Specificity	Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.
Function	Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.

Product Details

Product Type	Protein
Species	Mouse
Source	HEK 293 Cells
Tag	His
Endotoxin Level	<1.0 Eu/µg
Protein Length	Protein fragment
Molecular Weight	23 kDa
Purity	>95%
Active	No
Animal free	No
Nature	Recombinant
Application	SDS-PAGE

Storage & Handling

Shipping	Shipped at Room Temperature.
Storage	Store at -20 °C or -80 °C.
Handling	Avoid freeze / thaw cycle.