Recombinant Mouse RANKL Protein

Target Information

Sequence	YFRAQMDPNR ISEDSTHCFY RILRLHENAD LQDSTLESED TLPDSCRRMK QAFQGAVQKE LQHIVGPQRF SGAPAMMEGS WLDVAQRGKP EAQPFAHLTI NAASIPSGSH KVTLSSWYHD RGWAKISNMT LSNGKLRVNQ DGFYYLYANI CFRHHETSGS VPTDYLQLMV YVVKTSIKIP SSHNLMKGGS TKNWSGNSEF HFYSINVGGF FKLRAGEEIS IQVSNPSLLD PDQDATYFGA FKVQDID
Sequence Similarities	Belongs to the tumor necrosis factor family.
Amino Acids	70 to 316
Cellular Localization	Cytoplasm. Secreted and Cell membrane.
Tissue Specificity	Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.
Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Product Details

Product Type	Protein
Species	Mouse
Source	HEK 293 Cells
Endotoxin Level	≤0.005 Eu/µg
Protein Length	Full length protein
Molecular Weight	28 kDa
Purity	≥95%
Active	Yes
Animal free	Yes
Nature	Recombinant
Application	Cell Culture, FuncS, HPLC, MS, SDS-PAGE

Storage & Handling

Shipping	Shipped at Room Temperature.
Storage	Store at Room Temperature.
Handling	Avoid freeze / thaw cycle.