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RGLS4326

Cat. No.: IBDI-437942

RGLS4326 (RG4326) is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM.

Size (Solid):

Product Details

Target Others
Molecular Weight 3082.42
Appearance Solid
Synonyms RG4326
Sequence 5’-AsGsCmAfCfUfUmUsGs-3‘
SMILES OC[[email protected]@]1(O[[email protected]@H](N2C3=NC=NC(N)=C3N=C2)[[email protected]]4([H])O[[email protected]]1C)[[email protected]]4OP(OC[[email protected]]56[[email protected]]([[email protected]](O[[email protected]]6C)([H])[[email protected]](N7C8=C(C(N=C(N8)N)=O)N=C7)O5)OP(OC[[email protected]@H]9[[email protected]]([[email protected]]([[email protected]](N%10C(N=C(C=C%10)N)=O)O9)OC)OP(OC[[email protected]@H]%11[[email protected]]([[email protected]]([[email protected]](N%12C%13=NC=NC(N)=C%13N=C%12)O%11)F)OP(OC[[email protected]@H]%14[[email protected]]([[email protected]]([[email protected]](N%15C(N=C(C=C%15)N)=O)O%14)F)OP(OC[[email protected]@H]%16[[email protected]]([[email protected]]([[email protected]](N%17C(NC(C=C%17)=O)=O)O%16)F)OP(OC[[email protected]@H]%18[[email protected]]([[email protected]]([[email protected]](N%19C(NC(C=C%19)=O)=O)O%18)OC)OP(OC[[email protected]]%20%21[[email protected]]([[email protected]](O[[email protected]]%21C)([H])[[email protected]](N%22C(NC(C=C%22)=O)=O)O%20)OP(OC[[email protected]@]%23%24O[[email protected]@H](N%25C%26=C(C(N=C(N%26)N)=O)N=C%25)[[email protected]@](O[[email protected]]%24C)([H])[[email protected]@H]%23O)(S)=O)(S)=O)(S)=O)(S)=O)(S)=O)(S)=O)(S)=O)(S)=O
Purity 97.14%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.