RM-018

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Inquiry

Cat. No.: IBDI-436072

RM-018 is a potent, functionally distinct tricomplex KRAS G12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRAS G12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRAS G12C.

Size (Solid):

Product Details

Target	Ras
Molecular Weight	985.22
Appearance	Solid
SMILES	O=C(N1CCC[[email protected]@H](C(OCC(C)(C)CC2=[[email protected]@]([[email protected]@]3=C([[email protected]](C)OC)N=CC=C3)N(CC)C4=C2C=C5C=C4)=O)N1)[[email protected]@H](NC([[email protected]](C(C)C)N(C)C([[email protected]]6CCN(C(C#CCN7CCOCC7)=O)C6)=O)=O)CC8=CC=CC5=C8
Purity	98.03%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.