RMC-6272

Cat. No.: IBDI-435133

RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors.

Product Details

Target	mTOR
Molecular Weight	1850.22
Appearance	Solid
Synonyms	RM-006
SMILES	O=C(C1=C(C(F)=C(C=C1)S(CCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O[[email protected]]2[[email protected]@H](C[[email protected]@H](CC2)C[[email protected]]([[email protected]@]3([H])OC([[email protected]@]4([H])N(CCCC4)C(C([[email protected]@]5(O[[email protected]](CC[[email protected]]5C)([H])C[[email protected]@H](/C(C)=C/C=C/C=C/[[email protected]](C[[email protected]](C([[email protected]@H]([[email protected]@H](/C(C)=C/[[email protected]]([[email protected]@H](C3)O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O)=O)(=O)=O)C)N6CC7=CC(C8=CN=C(N)C=C8)=CC=C7OCC6
Purity	95.54%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.