Cat. No.: IBDA-431357
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Online InquiryTarget Information
| Target Name | RNF216 |
| Uniprot ID | Q9NWF9 |
| Cellular Localization | Cytoplasm. |
| Immunogen | Synthetic peptide within Human RNF216 aa 100-150. |
| Function | Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. |
Product Details
| Description | Rabbit polyclonal antibody to RNF216. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Mouse, Human |
| Immunogen | Synthetic peptide within Human RNF216 aa 100-150. |
| Positive Control | WB: HeLa, HEK-293T, Jurkat and TCMK-1 whole cell lysates. IP: HeLa whole cell lysate. |
| Application | IP, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7 Preservative: 0.09% Sodium Azide Constituent: Tris Citrate/Phosphate |
| Handling | Avoid freeze-thaw cycles. |