Rocaglamide

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Cat. No.: IBDI-430032

Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.

Size (Solution): 10 mM * 1 mL in DMSO

Size (Solid + Solvent): 10 mM * 1 mL ready for reconstitution

Size (Solid):

Product Details

Target	NF-κB \| HSP \| Eukaryotic Initiation Factor (eIF)
Molecular Weight	505.56
Appearance	Solid
Synonyms	Roc-A
SMILES	O1C2=CC(OC)=CC(OC)=C2[[email protected]]2(O)[[email protected]](O)[[email protected]](C(N(C)C)=O)[[email protected]@H](C3=CC=CC=C3)[[email protected]]12C1=CC=C(OC)C=C1 \|&1:11,13,15,21,28,r\|
Structure Classification	Alkaloids
Purity	98.61%

Storage & Handling

Shipping	Room temperature in continental US. May vary elsewhere.
Storage	Powder: -20°C/3 years; 4°C/2 years In solvent: -80°C/6 months; -20°C/1 month
Regulatory Status	This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.

! For research use only, not intended for any clinical use.