S100A9 Monoclonal Antibody

Target Information

Target Name	S100A9
Uniprot ID	P06702
Cellular Localization	Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
Immunogen	Recombinant full length protein, corresponding to amino acids 1-113 of Mouse S100A9.
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.

Product Details

Description	Rat monoclonal antibody to S100A9.
Host Species	Rat
Clonality	Monoclonal
Purity	Protein G purified
Isotype	IgG2a
Conjugation	Unconjugated
Reactivity	Mouse, Human
Immunogen	Recombinant full length protein, corresponding to amino acids 1-113 of Mouse S100A9.
Positive Control	Neutrophils FFPE mouse lung tissue sections RAW246.7 cell line
Application	ICC/IF, IHC-P

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Upon delivery aliquot. Store at -20 °C or -80 °C
Storage Buffer	Constituent: PBS
Handling	Avoid freeze-thaw cycles.