S100A9 Polyclonal Antibody

Target Information

Target Name	S100A9
Uniprot ID	P06702
Cellular Localization	Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
Immunogen	Recombinant full length protein corresponding to Mouse S100A9 aa 1 to the C-terminus.
Function	Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.

Product Details

Description	Rabbit polyclonal antibody to S100A9.
Host Species	Rabbit
Clonality	Polyclonal
Purity	Protein G purified
Isotype	IgG
Conjugation	Unconjugated
Reactivity	Mouse
Immunogen	Recombinant full length protein corresponding to Mouse S100A9 aa 1 to the C-terminus.
Positive Control	WB: Mouse brain lysate. IP: Mouse spleen lysate.
Application	IP, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Short term: 4 °C. Long term: -20 °C
Storage Buffer	pH: 7.40 Constituent: 50% Glycerol, PBS, 0.03% Proclin 300
Handling	Avoid freeze-thaw cycles.