Cat. No.: IBDA-434688
Size:
Online InquiryTarget Information
| Target Name | S100A9 |
| Uniprot ID | P06702 |
| Cellular Localization | Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation. |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human S100A9. |
| Function | Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions. |
Product Details
| Description | Rabbit polyclonal antibody to S100A9. |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Purity | Immunogen affinity purified |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human S100A9. |
| Positive Control | Recombinant Human S100A9 protein can be used as a positive control in WB. This antibody gave a positive signal in the following Human Tissue Lysates: Lymph node, Thymus, Spleen, Lung This antibody gave a positive result in IHC in the following FFPE tissue: Human Tonsil. |
| Application | ICC/IF, IHC-P, WB |
Storage & Handling
| Shipping | Shipped at 4 °C. |
| Storage | Short term: 4 °C. Long term: -20 °C |
| Storage Buffer | pH: 7.40 Preservative: 0.02% Sodium Azide Constituent: PBS |
| Handling | Avoid freeze-thaw cycles. |