Cat. No.: IBDA-432602
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Online InquiryTarget Information
Target Name | SDF1 Alpha |
Uniprot ID | P48061 |
Cellular Localization | Secreted. |
Immunogen | Recombinant fragment corresponding to Rat SDF1 alpha aa 1 to the C-terminus. |
Function | Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase. |
Product Details
Description | Biotin Rabbit polyclonal antibody to SDF1 alpha. |
Host Species | Rabbit |
Clonality | Polyclonal |
Purity | Affinity purified |
Isotype | IgG |
Conjugation | Biotin |
Reactivity | Recombinant fragment |
Immunogen | Recombinant fragment corresponding to Rat SDF1 alpha aa 1 to the C-terminus. |
Application | ELISA |
Storage & Handling
Shipping | Shipped at 4 °C. |
Storage | Store at -20ºC. Store in the dark |
Storage Buffer | Constituent: PBS, 0.1% BSA |
Handling | Avoid freeze-thaw cycles. |