Products
Inquiry

* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

SDF1 Alpha Polyclonal Antibody

Cat. No.: IBDA-432602

Size:

Target Information

Target Name SDF1 Alpha
Uniprot ID P48061
Cellular Localization Secreted.
Immunogen Recombinant fragment corresponding to Rat SDF1 alpha aa 1 to the C-terminus.
Function Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the Lyn kinase. Stimulates migration of monocytes through its receptor, CXCR4, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through Lyn kinase.

Product Details

Description Biotin Rabbit polyclonal antibody to SDF1 alpha.
Host Species Rabbit
Clonality Polyclonal
Purity Affinity purified
Isotype IgG
Conjugation Biotin
Reactivity Recombinant fragment
Immunogen Recombinant fragment corresponding to Rat SDF1 alpha aa 1 to the C-terminus.
Application ELISA

Storage & Handling

Shipping Shipped at 4 °C.
Storage Store at -20ºC. Store in the dark
Storage Buffer Constituent: PBS, 0.1% BSA
Handling Avoid freeze-thaw cycles.
! For research use only, not intended for any clinical use.