SDF1 Beta Polyclonal Antibody

Target Information

Target Name	SDF1 Beta
Uniprot ID	P48061
Cellular Localization	Secreted.
Immunogen	Recombinant fragment corresponding to Human SDF1 beta aa 1 to the C-terminus.
Function	Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Product Details

Description	Biotin Goat polyclonal antibody to SDF1 beta.
Host Species	Goat
Clonality	Polyclonal
Purity	Affinity purified
Isotype	IgG
Conjugation	Biotin
Reactivity	Recombinant fragment
Immunogen	Recombinant fragment corresponding to Human SDF1 beta aa 1 to the C-terminus.
Positive Control	WB: Recombinant human SDF1 beta protein.
Application	sELISA, WB

Storage & Handling

Shipping	Shipped at 4 °C.
Storage	Store at -20ºC. Store in the dark
Storage Buffer	Constituent: PBS, 0.1% BSA
Handling	Avoid freeze-thaw cycles.