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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Semapimod tetrahydrochloride

Cat. No.: IBDI-431379

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders.

Size (Solid):

Product Details

Target TNF Receptor | Interleukin Related | p38 MAPK
Molecular Weight 890.74
Appearance Solid
Synonyms CNI-1493, CPSI-2364 tetrahydrochloride
SMILES O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Purity 98.43%

Storage & Handling

Shipping Room temperature in continental US. May vary elsewhere.
Storage -20°C
*In solvent : -80°C, 6 months; -20°C, 1 month
Handling Sealed storage, away from moisture and light
Regulatory Status This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use.
! For research use only, not intended for any clinical use.
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